Anticomplement agent.
نویسندگان
چکیده
منابع مشابه
Anticomplement therapy
The complement system is an important part of innate immunity; however, as with other parts of the immune system, the complement system can become pathologically activated and create or worsen disease. Anticomplement reagents have been studied for several years, but only recently have they emerged as a viable therapeutic tool. Here, we describe the role of the complement system in a wide array ...
متن کاملEffect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig-to-rat xenotransplantation.
THE anticomplement agent K-76 COOH (K76). which mainly inhibits C5 activation. has been effectively used to mitigate experimental immune complex glomerulonephritis and ulcerative colitis.1.2 The effectiveness of K76. alone or in combination with FK 506 and cyclophosphamide (CP). in preventing xenograft rejection was studied using the hamster-to-rat and guinea pig-to-rat heart transplantation mo...
متن کاملAn anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice.
Activation of complement is a key determinant of neuropathology and disability after traumatic brain injury (TBI), and inhibition is neuroprotective. However, systemic complement is essential to fight infections, a critical complication of TBI. We describe a targeted complement inhibitor, comprising complement receptor of the Ig superfamily (CRIg) fused with complement regulator CD59a, designed...
متن کاملEffect of anticomplement agent K76 COOH on hamster-to-rat and guinea pig-to-rat heart xenotransplantation.
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well beyond the drug's 3-hr half-life. It was tested alone and with intramuscular tacrolimus (TAC) and/or intragastric cyclophosphamide (CP) in rat r...
متن کاملThe potential of anticomplement synthetic sulfonic polymers for xenotransplantation.
IN IMMEDIATELY vascularized xenografts, the presence of species-specific preformed natural antibodies associated with the activation of the host complement system has been reported to induce hyperacute humoral rejection in discordant combinations. Furthermore, complement activation on the endothelial cells of xenografts has been suggested to play a major role in hyperacute rejection. On the oth...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1980
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)53389-3